By Jim E. Riviere(auth.)
Now in a revised variation, Comparative Pharmacokinetics: ideas, concepts, and Applications offers the rules and methods of comparative and veterinary pharmacokinetics in an in depth but functional demeanour. constructed as a device for making sure that pharmacokinetics reports are competently designed and properly interpreted, the e-book offers entire assurance of the conceptual foundation of pharmacokinetics as used for quantifying organic approaches from the views of body structure and medicine. New chapters were additional on quantitative constitution permeability relationships and bioequivalence, and a few present chapters were considerably revised and multiplied to supply a present source for veterinary and comparative pharmacokinetics.Content:
Chapter 1 advent (pages 3–11):
Chapter 2 rules of Drug stream within the physique (pages 13–25):
Chapter three Quantitative Structure–Permeability Relationships (pages 27–38): Xin?Rui Xia
Chapter four Absorption (pages 39–71):
Chapter five Distribution (pages 73–90): Jennifer Buur
Chapter 6 Renal removal (pages 91–111):
Chapter 7 Hepatic Biotransformation and Biliary Excretion (pages 113–141): Ronald Baynes
Chapter eight Compartmental types (pages 143–186):
Chapter nine Noncompartmental types (pages 187–206):
Chapter 10 Nonlinear versions (pages 207–223):
Chapter eleven Physiological versions (pages 225–240): Teresa Leavens
Chapter 12 Dosage Regimens (pages 241–254):
Chapter thirteen Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (pages 255–294): Pierre?Louis Toutain
Chapter 14 learn layout and information research (pages 295–313): Jason Chittenden
Chapter 15 Bioequivalence stories (pages 315–346): Marilyn Martinez
Chapter sixteen inhabitants Pharmacokinetic types (pages 347–378): Jason Chittenden
Chapter 17 Dosage alterations in affliction States (pages 379–397): Jennifer Davis
Chapter 18 Interspecies Extrapolations (pages 399–412):
Chapter 19 Tissue Residues and Withdrawal instances (pages 413–424):
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Extra info for Comparative Pharmacokinetics: Principles, Techniques, and Applications, Second Edition
Finally, this chapter has focused on using QSPeR models as illustrative of the QSAR process in general since membrane transport is central to pharmacokinetic modeling. However, QSAR is a much broader discipline and has been used to relate a wide variety of molecular properties to a number of biological end points including drug receptor binding and activity, chemical and drug toxicity, and drug interaction with all levels of the genome. , 2010). QSPeR analysis shows the power of using mathematical models to probe interactions between drugs and biological systems.
These data were a compilation from 15 different literature sources. These data are expected to contain a high degree of experimental error due to interlaboratory variability, particularly variability arising from the use of skin from different sources and location on the body. , 1999). It was postulated that the steroids may penetrate the skin by a different mechanism from other molecules. , 1995) indicated that the steroid data in Flynn’s data set were substantially different from those found in a range of other literature sources, and concluded that they may be erroneous.
36 Comparative Pharmacokinetics Our laboratory also explored methods to assess how formulation or vehicles affect Kp (Riviere and Brooks, 2005, 2007). In the discussion to this point, we have defined Kp specifically for a molecule in a specific experimental system. The skin Kp data used above was defined using water as a vehicle. However, most environmental and occupational exposures occur in complex chemical mixtures, and all topical drugs are formulated in vehicles. As can be seen in Fig. 10 Hat Training set (384) Validation set (47) Fig.
Comparative Pharmacokinetics: Principles, Techniques, and Applications, Second Edition by Jim E. Riviere(auth.)