By Michael Bader
Edited by means of a well known scientist within the box with greater than two hundred excessive profile medical courses to his identify, this is often the 1st e-book to supply a accomplished evaluate of all cardiovascular hormone platforms. essentially established, the textual content covers steroid and peptide hormones, amines, and arachidonic acid metabolites, to boot as nucleotides, nitric oxide, and acetylcholine. a necessary reference for researchers engaged on the cardiovascular procedure and similar ailments.
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Additional info for Cardiovascular Hormone Systems: From Molecular Mechanisms to Novel Therapeutics
Circulation Research, 39, 788–97. K. A. (2000) Pituitary–adrenal axis regulation in CRH-deﬁcient mice. Endocrine Research, 26, 1057–66. F. and Rivier, C. (1999) CRF type I receptor-deﬁcient mice exhibit a pronounced pituitary– adrenal response to local inﬂammation. Endocrinology, 140, 1013–7. W. F. (2002) Mice deﬁcient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. Journal of Neuroscience, 22, 193–9.
Hypertension is one of the most important cardiovascular risk factors associated with Cushing’s syndrome, being present in around 80% of adult patients . The hypertensive phenotype is an effect of interactions between several of the associated pathophysiological mechanisms underlying Cushing’s syndrome including effects upon plasma volume, peripheral vascular resistance and cardiac output, all of which have a tendency to be increased . Cushing’s associated blood pressure abnormalities present initially with a deregulation of blood pressure circadian rhythm, characterized by a loss of the typical nocturnal fall.
Furthermore, glucocorticoids demonstrably inﬂuence the phase of peripheral oscillators in the kidney, heart and liver, although not in the central “clock” of the supra chiasmatic nuclei . 3 Corticosteroid Receptors and Control of Ligand Access suggest that disturbances in HPA signaling are connected with vulnerability to behavioral abnormalities . Moreover, there is a well-established circadian variation in cardiovascular risk events, with an increase in events in the morning compared to other times of day , coinciding with elevated glucocorticoid and aldosterone levels.
Cardiovascular Hormone Systems: From Molecular Mechanisms to Novel Therapeutics by Michael Bader