By Mohammed S. Razzaque, Takashi Taguchi
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Extra info for Cardiovascular Disorders in Hemodialysis: 14th International Course on Hemodialysis, Vicenza, May 2005 (Contributions to Nephrology)
Nephrol Dial Transplant 1999;14:2607–2613. Locatelli F, Covic A, Chazot C, Leunissen K, Luno J, Yaqoob M: Optimal composition of the dialysate, with emphasis on its influence on blood pressure. Nephrol Dial Transplant 2004;19: 785–796. Schneditz D, Levin NW: Non invasive blood volume monitoring during hemodialysis: Technical and physiological aspects. Semin Dial 1997;10:166–169. Mitra S, Chamney P, Greenwood R, Farrington K: The relationship between systemic and whole-body hematocrit is not constant during ultrafiltration on hemodialysis.
In view of overcoming this drawback, a semi-empirical, lumped-parameter mathematical model for characterization of IF phenomena was developed. The model considers a dialyzer as composed by N adjacent axial blocks. For each block, hydrodynamics in the blood and dialysate compartments are determined considering hydraulic resistance and calculating local filtration. Blood viscosity and oncotic pressure are calculated locally based on hematocrit and protein concentration. , Tokyo, Japan) dialyzers.
The set of equations describing the model is numerically solved by an iterative routine essentially based on the Newton-Rhaphson method. The time needed for a typical problem to be solved is far less than one second with a common personal computer, so that the user may work with the program in quite an interactive way. e. Hct ϭ 33% and Cp ϭ 7 g/dl) and at QUF ϭ 0, the effect exerted by changing blood or dialysate flow rates may be evaluated. 8 UL are shown in figure 2 (upper panels): IF/BF rate is more sensitive to blood flow rate changes (upper left graph) than to dialysate (upper right graph).
Cardiovascular Disorders in Hemodialysis: 14th International Course on Hemodialysis, Vicenza, May 2005 (Contributions to Nephrology) by Mohammed S. Razzaque, Takashi Taguchi