By M.J. Janse, M.R. Rosen (auth.)
This ebook contains the main up-to date info relating to mechanisms and therapy of cardiac arrhythmia. a number of the issues mentioned during this textual content replicate very lately undertaken learn instructions together with genetics of arrhythmias, mobilephone signalling molecules as power healing pursuits and trafficking to the membrane. those new ways and implementations of anti-arrhythmic remedy derive from many a long time of analysis as defined within the first bankruptcy by way of extraordinary Professors Michael Rosen (Columbia college) and Michiel Janse (University of Amsterdam). The textual content covers alterations in techniques to remedy over the years, arrhythmias in a number of cardiac areas and over many scales, from gene to protein to phone to tissue to organ.
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Extra resources for Basis and Treatment of Cardiac Arrhythmias
60 60 61 62 5 Conclusions . . . . . . . . . . . . . . . . . . 63 References . . . . . . . . . . . . . . . . . . . . 64 . . . . . . . . . . Abstract The ionic basis of automaticity in the sinoatrial node and His–Purkinje system, the primary and secondary cardiac pacemaking regions, is discussed. Consideration is given to potential targets for pharmacologic or genetic therapies of rhythm disorders. An ideal target would be an ion channel that functions only during diastole, so that action potential repolarization is not affected, and one that exhibits regional differences in expression and/or function so that the primary and secondary pacemakers can be selectively targeted.
Inward Currents of the Sino-atrial Node . . . . . . . . Outward Currents of the Sino-atrial Node . . . . . . . Regional Heterogeneity and Coupling to Atrial Tissue . . . . Bundle of His, Right and Left Bundle Branches and Purkinje Fibers Specialized Conducting Tissue Serves Two Roles . . . . . Membrane Currents in Purkinje Fibers and Myocytes that Flow During the Action Potential . . . . . . . . 3 Pacemaker Activity in Purkinje Fibers .
Inward Currents of the Sino-atrial Node . . . . . . . . Outward Currents of the Sino-atrial Node . . . . . . . Regional Heterogeneity and Coupling to Atrial Tissue . . . . Bundle of His, Right and Left Bundle Branches and Purkinje Fibers Specialized Conducting Tissue Serves Two Roles . . . . . Membrane Currents in Purkinje Fibers and Myocytes that Flow During the Action Potential . . . . . . . . 3 Pacemaker Activity in Purkinje Fibers . . . . . . . . 3 Targets for Selective Intervention .
Basis and Treatment of Cardiac Arrhythmias by M.J. Janse, M.R. Rosen (auth.)