Atherosclerosis, large arteries and cardiovascular risk - download pdf or read online

By Michel E. Safar, Edward D. Frohlich

ISBN-10: 3805581769

ISBN-13: 9783805581769

This ebook offers the present considering overseas specialists concerning the underlying mechanisms of cardiovascular chance in addition to the pathogenesis and pathophysiology of impaired huge arterial stiffness and diminished huge arterial distensibility. It additionally demonstrates the reason for the current method of the administration and therapy of hypertensive illnesses and atherosclerosis. The specified readership contains easy scientists in vascular body structure in addition to physicians and scientists in cardiovascular drugs, diabetes mellitus and renal illnesses.

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Exercise conditioning in rats reduces sympathetic nervous activity and lowers BP but does not affect the proportion of elastin or arterial wall constituents [30]. There are several lines of evidence that suggest a role for the renin-angiotensin-aldosterone system as an important modulator of arterial properties. Angiotensin II increases aortic wall thickness and stiffness in rats [31, 32]. Aldosterone administration reversibly increases rat aortic stiffness and fibronectin content in dose-dependent Izzo /Mitchell 24 fashion independent of wall stress, with no changes in collagen or elastin [33].

G. sympathetic nervous and renin-angiotensin or local nitric oxide generative) that control vascular tone have relatively complex effects on local and systemic vascular elastic properties as described above. The in vivo regional response to inAging and Arterial Structure-Function Relations 23 creased VSM tone is further complicated by the associated changes in MAP. A localized increase in smooth muscle tone will tend to increase Zc as noted above. However, when MAP increases because of associated changes in resistance vessel tone, large artery diameter and Zc may remain unchanged (or may increase) while PWV is likely to be increased because of the attenuated dependency of PWV on R.

SAVE investigators. Survival and Ventricular Enlargement. Circulation 1997; 96:4254–4260. Franklin SS, Khan SA, Wong ND, Larson MG, Levy D: Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation 1999; 100:354–360. Chae CU, Pfeffer MA, Glynn RJ, Mitchell GF, Taylor JO, Hennekens CH: Increased pulse pressure and risk of heart failure in the elderly. JAMA 1999; 281:634–639. Domanski MJ, Davis BR, Pfeffer MA, Kastantin M, Mitchell GF: Isolated systolic hypertension: prognostic information provided by pulse pressure.

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Atherosclerosis, large arteries and cardiovascular risk by Michel E. Safar, Edward D. Frohlich


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