By Bradley S. Fleenor, Adam J. Berrones
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Extra resources for Arterial Stiffness: Implications and Interventions
Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson O, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ (2011) Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility— Reykjavik study. Brain 134(pt 11):3398–3407. 1093/brain/awr253 69. Kidher E, Patel VM, Nihoyannopoulos P, Anderson JR, Chukwuemeka A, Francis DP, Ashrafian H, Athanasiou T (2014) Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement.
These findings were similar in Amsterdam Growth and Health Longitudinal Study, in which they found that an increase of trunk mass by 10 kg was positively associated with carotid Young’s elastic modulus . In short, the magnitude of abdominal visceral fat accumulation appears to be an important contributor of large artery stiffening in adults [40, 42]. In addition to short-term weight gain, chronic obesity in adults results in significant metabolic burden due to excessive fat storage, and ultimately, a clinical manifestation of arterial dysfunction.
Am J Hypertens 26(1):20–26. 1093/ ajh/hps014 39. Huynh Q, Blizzard L, Sharman J, Magnussen C, Schmidt M, Dwyer T, Venn A (2013) Relative contributions of adiposity in childhood and adulthood to vascular health of young adults. Atherosclerosis 228(1):259–264. 022 40. Orr JS, Gentile CL, Davy BM, Davy KP (2008) Large artery stiffening with weight gain in humans: role of visceral fat accumulation. Hypertension 51(6):1519–1524. 112946 41. Schouten F, Twisk JW, de Boer MR, Stehouwer CD, Serne EH, Smulders YM, Ferreira I (2011) Increases in central fat mass and decreases in peripheral fat mass are associated with accelerated arterial stiffening in healthy adults: the Amsterdam Growth and Health Longitudinal Study.
Arterial Stiffness: Implications and Interventions by Bradley S. Fleenor, Adam J. Berrones