By Tomoyoshi Nozaki, Alok Bhattacharya
This booklet files and offers new advancements within the research of amebiasis, one of many ignored tropical illnesses. approximately 50 million humans around the world are contaminated with the pathogen Entamoeba histolytica, inflicting large-scale morbidity and mortality fairly in constructing nations. This ebook may help clinicians for greater analysis and administration of the ailment, researchers for beginning examine initiatives on many of the poorly understood points of the illness and the pathogen, and scholars for updating their wisdom. the topics coated variety from genomics and molecular and mobile biology to drug resistance and new drug improvement, highlighting significant advances in recent times in our knowing because of speedy development in genomic and different biomedical applied sciences, reminiscent of visualization of molecular techniques. lots of the chapters supply contemporary info in response to newest courses. a number of chapters describe many of the serious methodological concerns that may be worthy for college students and researchers attracted to moving into the sphere. The contributing authors contain just about all the lively researchers and clinicians from world wide. This publication can be an invaluable fundamental fabric and a precious resource of data for an individual attracted to figuring out amebiasis, its prognosis, and remedy. it's going to even be valuable to people who have an interest in studying concerning the biology of early branching eukaryotes and protist pathogens.
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Extra resources for Amebiasis: Biology and Pathogenesis of Entamoeba
Analyses of the E. histolytica and E. dispar genomes indicate recent active transposition [83, 85, 86]. The positions of SINE retrotransposons commonly differ between E. histolytica and E. dispar genomes, and even those occurring in orthologous positions appear to have arisen from independent insertions in the two species lineages . However, relatively little is known about intraspeciﬁc variation among transposons. 7 Intraspeciﬁc Variation Among Entamoeba Genomes Among E. histolytica, a number of studies have described intraspeciﬁc and intrapopulation diversity.
Bapteste E, Brinkmann H, Lee JA, Moore DV, Sensen CW, Gordon P, Duruﬂé L, Gaasterland T, Lopez P, Müller M, Philippe H (2002) The analysis of 100 genes supports the grouping of three highly divergent amoebae: Dictyostelium, Entamoeba, and Mastigamoeba. Proc Natl Acad Sci USA 99(3):1414–1419 17. Stensvold CR, Lebbad M, Victory EL, Verweij JJ, Tannich E, Alfellani M, Legarraga P, Clark CG (2011) Increased sampling reveals novel lineages of Entamoeba: consequences of genetic diversity and host speciﬁcity for taxonomy and molecular detection.
The reptile parasite Entamoeba invadens is more distantly related to E. histolytica. It is primarily studied as a model for the process of cyst formation because, in contrast to E. histolytica, it can be induced to encyst in axenic laboratory culture. The axenized IP-1 strain has been sequenced by whole genome shotgun Sanger sequencing, and the assembly is available via GenBank (under accession PRJNA12926) and amoebaDB. The genome is larger than that of E. histolytica or E. dispar (approximately 41 million base pairs of DNA in 1,149 scaffolds) and is slightly less AT rich (approximately 70 % AT); 11,549 annotated genes span approximately 38 % of the genome.
Amebiasis: Biology and Pathogenesis of Entamoeba by Tomoyoshi Nozaki, Alok Bhattacharya